"GO AND INVENT SOMETHING, ZOLI!"
This call to Professor Zoltán Noszticzius came from his old university classmate and friend, Sándor Balogh, founding director of Szentkirályi Ásványvíz Kft. And indeed, this call was one of the inspirations behind the invention of the hyperpure chlorine dioxide solution.
COMPANY HISTORY
2007
Solumium Kft. Was established in 2007 to utilize the new Hungarian invention for producing hyperpure chlorine dioxide.
2008
The first product of our company was Solumium Dental, a professional dental disinfectant.
It was a big success: as a world-first, the use of hyperpure chlorine dioxide solution in dental practice was introduced in Hungary in 2008.
Solumium Dental quickly became popular among Hungarian dentists as they found it to be more effective and gentler (free of side effects) than other products in dental and oral surgery applications, as well as skin and mucosal disinfection.
They used it primarily to disinfect the root canal, an application in which Solumium replaced sodium hypochlorite products. They also used Solumium to treat aphthous, herpes and other oral infections, and to reduce inflammation. The positive experiences were published in a series of articles in the Hungarian professional journal Dental Hírek (Dental News). [31]
Solumium has also gained a reputation abroad, with Austrian, Swiss, and American doctors and dentists among those integrating it in their professional practice.
2009
Our second product was Solumium Oral skin and mucous membrane disinfectant, which was used successfully by physicians and patients to relieve the symptoms of colds, sore throats, fungal and other skin infections, bedsores, and epithelial injuries, among others. [32]
2012
Solumium Oral was used in a successful clinical trial for the treatment of difficult-to-heal wounds. [32]
2015
In 2015, Solumium won the "Gran Prize" of the Swedish Chamber of Commerce.
2016
Adapting to the changing regulatory environment, Solumium products were registered as a medical device in 2016.
We were very pleased to see the number of our customers growing and the popularity of our products rising steadily among both physicians and home users.
2021
In May 2021, OGYÉI ordered the withdrawal of our products Solumium Dental and Solumium Oral from the market because, in their view, the products did not meet the definition of medical device.
We immediately started working on new Solumium products to make hyperpure chlorine dioxide available again.
2022
Our new products are: Solumium Coral and Solumium Pental.
Hyperpure chlorine dioxide is now manufactured and marketed as a mouthwash concentrate.
THE PRESENT
The hyperpure chlorine dioxide solution is currently marketed as a mouthwash. Our products are Solumium Coral and Solumium Pental mouthwash concentrates.
Once again, we would like to thank the doctors and our many users who have persevered and continue to put their trust in us. Thank you for your enthusiastic and useful feedback to help us improve our products and ensure the success of Solumium.
THE INVENTORS
The scientific research and experiments related to the invention were conducted by Professor Zoltán Noszticzius and his colleagues, who are presented below:
Dr. Zoltán Noszticzius
Solumium project manager. Chemical engineer, doctor of chemical science, Széchenyi-, Polányi- and Swedish Gran Prize Laureate. He is a specialist in oscillating reactions.
He is currently Professor Emeritus at the Budapest University of Technology and Economics.
Dr. Wittmann Marian, PhD
Biological engineer, associate professor at BME. She is a specialist in chemical mechanisms, and modeling of reaction systems.
Dr. Kristóf Kály-Kullai, PhD
Engineering physicist. He spent two years as a postdoctoral fellow researcher at the German Cancer Research Center in Heidelberg. Kristóf's expertise in the modeling of biochemical systems proved to be useful when studying the mechanism of action of Solumium.
Marianna Megyesi
She graduated from BME in chemical engineering. She is an expert in chemical analysis.
She is one of the most active participants in the series of experiments related to the invention.
Dr. András Volford, PhD
Chemical engineer, programmer. He graduated as a pharmaceutical engineer at BME.
He participated in the Solumium project primarily as an IT professional.
He is currently an employee of ChemAxon as a chemical computer scientist.
REFERENCES:
- [1] WO/2008/035130 Patent Cooperation Treaty (PCT ): Permeation method and apparatus for preparing fluids containing high purity chlorine dioxide, International Preliminary Report on Patentability: 12. 02. 2009.
https://patentscope.wipo.int/search/en/WO2008035130
Based on Hungarian patent P 06 00735: Permeációs eljárás és berendezés nagytisztaságú klór-dioxidot tartalmazó fluidumok előállításához, published: 2009. 04. 28. Szabadalmi Közlöny 114, 4/II P122. - [2] USA patent US 8,512,671 B1: Permeation method and apparatus for preparing fluids containing high purity chlorine dioxide, 2013.08. 20.
https://pdfpiw.uspto.gov/.piw?docid=08512671 - [3] Chinese patent CN 101605720 B: Permeation method and apparatus for preparing fluids containing high purity chlorine dioxide, 2013. 09. 04.
https://patents.google.com/patent/CN101605720B - [4] Noszticzius Z., Wittmann M., Kály-Kullai K., Beregvári Z., Kiss I., Rosivall L., Szegedi J.: Chlorine dioxide is a size-selective antimicrobial agent, PLOS ONE 8(11), e79157 2013.
https://doi.org/10.1371/journal.pone.0079157 - [5] Wilson, C. L.; Droby, C. L. Microbal Food Contamination, CRC Press Boca Raton 2001, ISBN: 0849322294, p.12
For a table illustrating the effectiveness of chlorine dioxide click here. - [6] Tanner, R.: Comparative testing and evaluation of hard-surface disinfectants, J. Ind. Microbiol., 4, p. 145–154, 1989.
https://link.springer.com/article/10.1007/BF01569799 - [7] Sanekata T., Fukuda T., Miura T., Morino H., Lee C., Maeda K., Araki K., Otake T., Kawahata T., Shibata T.: Evaluation of the antiviral activity of chlorine dioxide and sodium hypochlorite against feline calicivirus, human influenza virus, measles virus, canine distemper virus, human herpesvirus, human adenovirus, canine adenovirus and canine parvovirus, Biocontrol Sci. 201015(2):45-9, 2010.
https://doi.org/10.4265/bio.15.45 - [8] Morino H., Fukuda T., Miura T., Lee C., Shibata T., Sanekata T.: Inactivation of feline calicivirus, a Norovirus surrogate, by chlorine dioxide gas, Biocontrol Sci; 14: 147–53, 2009.
https://doi.org/10.4265/bio.14.147 - [9] Junli H., Li W., Nenqi R., Li L. X., Fun S. R., Guanle Y.: Disinfection effect of chlorine dioxide on viruses, algae and animal planktons in water, Water Research, Vol. 31, Issue 3, p. 455-460, 1997.
https://doi.org/10.1016/S0043-1354(96)00276-X - [10] Simpson G. D., Miller R. F., Laxton G. D., Clements W. R. A focus on chlorine dioxide: the "ideal" biocide, Corrosion 93. New Orleans, La, March 8-12. paper No. 472., 1993.
http://www.clo2.gr/en/pdf/secure/chlorinedioxideidealbiocide.pdf - [11] Kim J. S., Park J. W., Kim D. J., Kim Y. K., Lee J. Y.: Direct effect of chlorine dioxide, zinc chloride and chlorhexidine solution on the gaseous volatile sulfur compounds, Acta odontologica Scandinavica, 72(8), p. 645–650, 2014.
https://doi.org/10.3109/00016357.2014.887770 - [12] Lubbers, J. R., Chauan, S. R. & Bianchine, J. R. Controlled clinical evaluations of chlorine dioxide, chlorite and chlorate in man, Env. Health Persp. 46, p. 57–62, 1982.
https://www.sciencedirect.com/science/article/pii/S0272059081800425 - [13] Ison A., Odeh I. N., Margerum D. W.: Kinetics and Mechanisms of Chlorine Dioxide and Chlorite Oxidations of Cysteine and Glutathione, Inorganic Chemistry 45, p. 8768-8775, 2006.
https://doi.org/10.1021/ic0609554 - [14] Napolitano M. J., Green B. J., Nicoson J. S., Margerum D. W.: Chlorine Dioxide Oxidations of Tyrosine, N-Acetyltyrosine, and Dopa, Chemical Research in Toxicology 18, p. 501-508, 2005.
https://doi.org/10.1021/tx049697i - [15] Stewart D. J., Napolitano M. J., Bakhmutova-Albert E. V., Margerum D. W.: Kinetics and Mechanisms of Chlorine Dioxide Oxidation of Tryptophan, Inorganic Chemistry 47, p. 1639-1647, 2008.
https://doi.org/10.1021/ic701761p - [16] ATSDR (Agency for Toxic Substances & Disease Registry): Toxicological Profile for Chlorine Dioxide and Chlorite, U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, Public Health Service, Agency for Toxic Substances and Disease Registry, September 2004.
http://www.atsdr.cdc.gov/toxprofiles/tp160.pdf - [17] USA patent US 8,623,392 B2: Morino H., Shibata T.: Allergen inactivating agent, 2014. 01. 07.
https://pdfpiw.uspto.gov/.piw?PageNum=0&docid=08623392 - [18] Kály-Kullai K., Wittmann M., Noszticzius Z., Rosivall L.: Can chlorine dioxide prevent the spreading of coronavirus or other viral infections? Medical hypotheses, Physiology International Vol. 107 Issue 1, 2020.
https://dx.doi.org/10.1556/2060.2020.00015 - [19] REGULATION (EC) No 1272/2008 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL on classification, labelling and packaging of substances and mixtures, amending and repealing Directives 67/548/EEC and 1999/45/EC, and amending Regulation (EC) No 1907/2006
https://eur-lex.europa.eu/legal-content/EN/TXT/HTML/?uri=CELEX:32008R1272&from=en - [20] Ishi G.: Solubility of chlorine dioxide, Chemical Engineering Japan, Volume 22, Issue 3, p. 153–4, 1958 (in Japanese).
https://doi.org/10.1252/kakoronbunshu1953.22.153 - [21] Synan J. F., MacMahon J. D., & Vincent G. P.: Chlorine Dioxide, A Development in the Treatment of Potable Water, Water Works & Sewer, 91:423, 1944.
- [22] Block S. S.: Disinfection, Sterilization, and Preservation (5th ed.), Lippincott, Williams & Wilkins 2001, ISBN 0-683-30740-1, p. 215.
- [23] Chen, Z.: A Focus on Chlorine Dioxide: The Promising Food Preservative, Journal of Experimental Food Chemistry, Vol. 3, Issue 1, 2017.
https://doi.org/10.4172/2472-0542.1000e107 - [24] Noszticzius, Z., Rosivall, L., Wittmann, M.: Universal weapon against microbes? - hyperpure chlorine dioxide, Természet Világa Magazine, Volume 141, Number 4, 2010 (in Hungarian).
https://www.termvil.hu/archiv/szamok/tv2010/tv1004/noszti.html - [25] Silwood, C. J. L., Grootveld, M. C., Lynch, E.: A multifactorial investigation of the ability of oral health care products (OHCPs) to alleviate oral malodour, Journal of Clinical Periodontology, Vol. 28, Issue 7, p. 634–641, 2001.
https://doi.org/10.1034/j.1600-051x.2001.028007634.x - [26] Kerémi B. et al.: Effects of Chlorine Dioxide on Oral Hygiene - A Systematic Review and Meta-analysis, Current Pharmaceutical Design, Vol. 26, Issue 25, p. 3015-3025, 2020.
https://doi.org/10.2174/1381612826666200515134450 - [27] It should be noted that sodium chlorite is also commonly referred to as "stabilized chlorine dioxide". This is a very misleading name that could make one think that sodium chlorite is actually chlorine dioxide, but it is somehow "stabilized". This is of course a complete mistake. An even bigger problem is that even the adjective "stabilized" is very often omitted. Sodium chlorite is obviously not chlorine dioxide. Trying to counterbalance this naming problem, manufacturers who use real chlorine dioxide in their products have started using the term "active chlorine dioxide" to emphasize the presence of actual chlorine-dioxide.
- [28] Noszticzius Z. et al.: How to check the purity of an unknown chlorine dioxide product?, Magyar Fogorvos Magazine, Volume 26, 2017/3, p. 132-137, 2017 (in Hungarian).
https://www.kamara.fogorvos.hu/?module=news&action=getfile&aid=41196 - [29] Shellis, R. P., Featherstone, J. D., Lussi, A.: Understanding the chemistry of dental erosion, Monographs in oral science, 25, p. 163–179, 2014.
https://doi.org/10.1159/000359943 - [30] Ablal M. A., Adeyemi A. A., Jarad F. D.:The whitening effect of chlorine dioxide—An in vitro study, Journal of Dentistry, Vol. 41, Supplement 5, p. e76-e81, 2013.
https://doi.org/10.1016/j.jdent.2013.05.006 - [31] Csikány, Cs., Várnai, G., Noszticzius, Z. SOLUMIUM DENTAL: the hyperpure chlorine dioxide solution and its application in dental practice I.-II.-III. Dental Hírek Magazine, issue 4, p. 30-33, issue 5, p. 36-38, issue 6, p. 56-57, 2009 (in Hungarian).
- [32] Noszticzius Z., Wittmann M., Kály-Kullai K., Beregvári Z., Kiss I., Rosivall L., Szegedi J.: Demonstrating that chlorine dioxide is a size-selective antimicrobial agent and high purity ClO2 can be used as a local antiseptic, arXiv: Other Quantitative Biology, 2013.
https://arxiv.org/pdf/1304.5163.pdf - [33] Daniel, F. B., Condie, L. W., Robinson, M., Stober, J. A., York, R. G., et al.: Comparative 90-day subchronic toxicity studies on three drinking water disinfectants, chlorine, monochloramine and chlorine dioxide in the Sprague-Dawley rats, Journal of American Water Works Association,Volume 82, Issue 10, p. 61–69, 1990.
https://doi.org/10.1002/j.1551-8833.1990.tb07038.x